Volume 6, Issue 2, June 2020, Page: 43-45
Cell Clusters in Cancer Metastasis: A Mini Review
Steven Oppenheimer, Department of Biology and Center for Cancer and Developmental Biology, California State University, Northridge, California, United States
Received: Apr. 20, 2020;       Accepted: May 7, 2020;       Published: May 19, 2020
DOI: 10.11648/j.ajasr.20200602.13      View  293      Downloads  175
Abstract
Evidence is accumulating that suggests that cancer cell clusters are more likely to lead to metastatic lesions than are single cells. This mini-review explores this issue by examining evidence that indicates that cell clusters possess altered genes and metabolism that promote metastasis. When clusters are disaggregated, the resulting single cells often lose the altered properties characteristic of when they were in clusters. When cluster disrupting agents were injected into mice, metastasis was reduced. Cluster disaggregating agents are described and mechanisms of action of these compounds are explored. Using these agents to target cell clusters might offer a useful therapeutic approach in the treatment of cancer. Cell clusters are also involved in thrombocytosis and biofilm infectivity as well as cancer spread and cluster disrupting agents might be very useful in treating some human conditions in addition to cancer spread. Assays that examine the effectiveness of cluster disrupting agents are also described.
Keywords
Clustered Cancer Cells, Cancer Metastasis, Cluster Disrupting Agents
To cite this article
Steven Oppenheimer, Cell Clusters in Cancer Metastasis: A Mini Review, American Journal of Applied Scientific Research. Vol. 6, No. 2, 2020, pp. 43-45. doi: 10.11648/j.ajasr.20200602.13
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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